Table 5. Toxicity functions at the gene level for each T2D subtype.
Toxicity functionsSubtype1Subtype2Subtype3Genes
Biliary hyperplasia3.5 × 10−3nsnsCFTR, PKHD1
Glutathione depletion in liver3.5 × 10−3nsnsLEPR, TGFB1
Liver fibrosis3.5 × 10−3nsnsTGFB1, LEPR, TGFB2, PKHD1
Glomerular injury4.7 × 10−3nsnsFYN, TGFB1, LEPR, RARA, TNS1, PKN1, PTGER1, BCL2
Renal hypertrophy4.7 × 10−3nsnsTGFB1, LEPR, RARA, BCL2
Liver damage5.1 × 10−3nsnsSLC10A1, TGFB1, IGF1R, GABBR1, SERPINA1,
CD274, PARK2, PTGER1
Liver inflammation/hepatitis5.1 × 10−3nsnsAKAP12, SLC10A1, TGFB1, PDE3A, IGF1R,
GABBR1, CD274, PARK2
Renal proliferation7.6 × 10−3nsnsPRKG1, TGFB1, UNC5B, TTLL4, CRK, ZNF512B,
DLC1, BCL2, UNC5C, AFF1
Renal degeneration8.0 × 10−3nsnsTGFB1, TNS1, BCL2
Cardiac arrhythmians1.0 × 10−3nsKCND3, HCN4, KCNG2, KCNQ1, CNTN5
Bradycardians4.9 × 10−3nsHCN4, KCNQ1
Cardiac arteriopathyns9.3 × 10−34.8 × 10−6Subtype 2: SAMD12, KALRN, ITGA8, PDE5A, DOCK4,
CNTN6, PRKCH, CSMD2, CPEB3, CNTN5
Subtype 3: CERS6, CLIC5, ZMYM2, CDCP1, ABCG1, FRMD4A,
PDE4B, PTPRM, ABCA1, F2, SPATA5, AKAP13, MCF2L, PBX3, CNTNAP5,
FMN2, CACNA2D1, SLC8A1, ESR2
Liver fibrosisnsns3.3 × 10−3FGF2, PLAUR, BMP7, CC2D2A, F2, HSPB1
Congenital heart anomalynsns5.8 × 10−3DNAH11, BICC1, PDS5B, INVS