Table 1.

Clinical variables specific to subtypes. S-1, subtype 1; S-2, subtype 2; S-3, subtype 3; BMI, body mass index.

(A) Clinical variables significantly specific to T2D subtype 1
Clinical variablesMean or % subtype 1Mean or % subtype 2Mean or % subtype 3P (1 versus 2 + 3)S-1S-2S-3
Platelet count (109/liter)98.36 ± 17.86228.24 ± 2.90228.61 ± 2.45<0.0001Y
Urine protein concentration (mg/dl)51.19 ± 14.38152.67 ± 37.21219.98 ± 47.620.0001Y
Lactate dehydrogenase (U/liter)193.35 ± 8.88231.03 ± 8.82251.34 ± 8.17<0.0001Y
Age (years)59.76 ± 0.4564.25 ± 0.5063.65 ± 0.38<0.0001Y
Blood urea nitrogen (mg/dl)16.69 ± 0.3519.38 ± 0.5919.52 ± 0.35<0.0001Y
Neutrophil count (109/liter)2.50 ± 0.584.78 ± 0.124.83 ± 0.090.0024Y
White blood cell count (109/liter)5.32 ± 0.577.28 ± 0.097.46 ± 0.070.001Y
Respirations16.65 ± 0.1617.50 ± 0.1417.62 ± 0.08<0.0001Y
Urine protein-to-creatinine ratio0.40 ± 0.091.19 ± 0.262.48 ± 0.45<0.0001YY
Serum creatinine (mg/dl)1.00 ± 0.021.25 ± 0.071.27 ± 0.04<0.0001Y
Eosinophil count (109/liter)0.09 ± 0.020.19 ± 0.010.20 ± 0.010.0003Y
Blood protein total (g/dl)7.49 ± 0.037.34 ± 0.047.14 ± 0.03<0.0001YY
Serum albumin (g/dl)4.27 ± 0.024.03 ± 0.034.04 ± 0.02<0.0001Y
Serum calcium (mg/dl)9.90 ± 0.029.66 ± 0.039.60 ± 0.02<0.0001Y
CO2 total26.60 ± 0.1326.05 ± 0.1526.16 ± 0.090.0011Y
Mean platelet volume (fl)9.97 ± 0.378.98 ± 0.058.97 ± 0.040.008Y
Prothrombin time* (s)29.18 ± 3.6414.10 ± 0.3314.13 ± 0.270.0005Y
INR*2.57 ± 0.341.19 ± 0.039.32 ± 0.410.0005Y
BMI33.07 ± 0.2931.32 ± 0.3031.19 ± 0.02<0.0001Y
Estimated GFR calculation (MDRD, ml/min/1.73 m2)74.86 ± 1.4768.40 ± 1.9965.04 ± 1.33<0.0001Y
GFR estimate (ml/min/1.73 m2)72.26 ± 1.4764.62 ± 1.7763.75 ± 1.22<0.0001Y
Glucose* (mg/dl)193.69 ± 11.45149.55 ± 4.18158.69 ± 2.900.0005Y
Insulin21.92%29.82%45.16%<0.0001YYY
Metformin6.43%23.01%21.17%<0.0001Y
Loop diuretics5.51%14.10%18.34%<0.0001Y
DPP41.05%6.48%6.39%<0.0001Y
CCBs19.55%30.63%35.31%<0.0001Y
β-Blocker21.92%39.06%45.80%<0.0001YY
ARB/ACEI48.16%57.05%62.96%<0.0001YY
Vasodilators0.92%5.02%5.57%<0.0001Y
Nicotinic acid derivatives0.13%1.30%1.37%0.02Y
(B) Clinical variables significantly specific to T2D subtype 2
Clinical variableMean or % subtype 1Mean or % subtype 2Mean or % subtype 3P (2 versus 1 + 3)S-1S-2S-3
Weight (kg)92.26 ± 1.0885.17 ± 1.1489.16 ± 0.83<0.0001Y
Troponin I level (ng/ml)00.03 ± 0.010.36 ± 0.090.0003YY
Insulin21.92%29.82%45.16%<0.0001YYY
(C) Clinical variables significantly specific to T2D subtype 3
Clinical variableMean or % subtype 1Mean or % subtype 2Mean or % subtype 3P (3 versus 1 + 2)S-1S-2S-3
Blood protein total (g/dl)7.49 ± 0.037.34 ± 0.047.14 ± 0.030YY
Urine protein-to-creatinine ratio0.40 ± 0.091.19 ± 0.262.48 ± 0.450.0006YY
Troponin I level (ng/ml)00.03 ± 0.010.36 ± 0.090.0003YY
Systolic blood pressure (mmHg)132.04 ± 0.73132.41 ± 0.92135.7 ± 0.70.0001Y
Serum chloride level (mEq/liter)101.01 ± 0.17101.45 ± 0.18102.03 ± 0.110Y
HMG-CoA reductase inhibitors (statins)42.26%45.71%56.39%<0.0001Y
Centrally acting antihypertensives1.44%1.30%4.11%0.0001Y
ARB/ACEI48.16%57.05%62.96%<0.0001YY
β-Blocker21.92%39.06%45.80%<0.0001YY
Insulin21.92%29.82%45.16%<0.0001YYY

*Point of care.