Table 1. Quantitative comparison of H&E histology and SRS microscopy.

Three neuropathologists (R1, R2, and R3) reviewed a series of 75 H&E-stained tissues and 75 matched SRS FOVs and rated the degree of tumor infiltration via a Web-based survey. The category indicated as “normal” in the table represents FOVs categorized as normal to minimally hypercellular tissue with scattered atypical cells.

DiagnosisModalityNeuropathologist R1Neuropathologist R2Neuropathologist R3Overall
accuracy (%)
CorrectIncorrectCorrectIncorrectCorrectIncorrect
NormalH&E25025024198.7
SRS24125025098.7
Infiltrating gliomaH&E141123225082.7
SRS25018724189.3
High-density gliomaH&E22325025096.0
SRS25025023297.3
TotalsH&E611473274192.4
SRS74168772395.1
Both135151419146493.8