Table 2. IGH gene usage of NAT-PML-IRIS patient–derived monoclonal antibodies.

The germline usage for heavy-chain variable region (VH), heavy-chain diversity region (DH), and heavy-chain joining region (JH) segments of IGH genes defined using the IMGT database and the number of amino acids in the CDR3 region as well as amino acid mutations as compared to the germline sequence are shown. aa, amino acids.

mAbVHDHJHCDR3 lengthaa mutations
98D33-30*145-5*014-1*021613/96
43E83-30*043-22*014-1*021419/95
105C73-23*042-15*014-1*021914/96
45E103-23*042-15*014-1*021913/96
29B13-23*043-22*014-1*021717/96
26A33-23*043-3*026-1*021713/96
58C73-11*016-13*014-1*021610/96
47B113-11*016-13*014-1*02165/96
56A83-21*011-1*014-1*02113/96
27C23-21*011-1*014-1*02118/96
72F73-48*033-3*016-1*02215/96
59A73-48*035-5*014-1*01164/96
57D43-9*014-17*016-1*02147/96
105A63-9*015-5*016-1*02142/96
72F103-9*015-12*014-1*021410/96
27C114-4*021-14*016-1*02205/96
50H44-4*021-14*016-1*02206/96
7J34-30.4*013-10*016-1*02203/97
98H14-31*033-22*016-1*022111/97
53B115-51*011-26*014-1*02133/96