Table 1. Radiographic findings in lungs of rhesus macaques inoculated with MERS-CoV between 1 and 6 days postinfection (dpi).

Images and clinical observations were made on days 1, 3, 5, and 6.

GroupAnimalDay 1Day 3Day 5Day 6
pVax1(6002)Interstitial infiltration present in both caudal lobesDiffuse interstitial infiltration present in both caudal lobes; bronchial pattern present in right middle lobeDiffuse interstitial infiltration present in both caudal lobes; bronchial pattern present in right middle lobeSerious diffuse interstitial infiltration present in both caudal lobes; bronchial pattern present in right middle lobe
(6003)Interstitial infiltration present in both caudal lobesDiffuse interstitial infiltration present in both caudal lobesDiffuse interstitial infiltration present in both caudal lobes and right middle lobeDiffuse interstitial infiltration present in both caudal lobes and right middle lobe
(6006)NormalInterstitial infiltration present in both caudal lobesInterstitial infiltration present in both caudal lobes; small mass in right caudal lobe; bronchial pattern present in both caudal lobesInterstitial infiltration present in both caudal lobes; small mass in right caudal lobe; bronchial pattern present in both caudal lobes
(6009)Interstitial infiltration present in both caudal lobes; air bronchograms observed in right middle lobeInterstitial infiltration present in both caudal lobes; air bronchograms observed in left caudal, right caudal, and middle lobesInterstitial infiltration present in both caudal lobes; air bronchograms observed in left caudal, right caudal, and middle lobesInterstitial infiltration present in both caudal lobes; air bronchograms observed in left caudal, right caudal, and middle lobes
MERS vaccine (high dose)(6001)NormalNormalNormalNormal
(6005)Interstitial infiltration present in both caudal and middle lobesInterstitial infiltration present in both caudal and middle lobesNormalNormal
(6008)NormalNormalNormalNormal
(6011)Interstitial infiltration present in both caudal and middle lobesInterstitial infiltration present in both caudal and middle lobes; air bronchograms observed in both caudal and middle lobesNormalNormal
MERS vaccine (low dose)(6000)NormalNormalNormalNormal
(6004)NormalNormalNormalNormal
(6007)NormalNormalNormalNormal
(6010)NormalNormalNormalNormal