Table 2. Effect of LPS on serum concentrations of histamine and serotonin.

Serum histamine concentrations were not affected by increasing doses of LPS. Serum serotonin concentrations were significantly decreased at all LPS doses compared to DPBS-treated mice (*P < 0.05, **P < 0.001, Mann-Whitney U test; n in table S1 at 3 hours after GTTR injection).

LPS dose
(mg/kg)
Histamine
(ng/ml ± SEM)
Serotonin
(ng/ml ± SEM)
033 (±2)2770 (±100)**
0.125 (±3)2135 (±285)**
1.024 (±4)579 (±157)**
2.528 (±3)830 (±246)**
1036 (±6)837 (±329)**