Table 1. Comparative kinetic analysis of DSM265 and derivatives on P. falciparum and mammalian DHODH.

Data represent mean of three technical replicates with 95% confidence intervals for the fit shown in parentheses. Primary data are provided in table S19. ND, not determined.

CompoundDSM265DSM430DSM450
DHODHIC50 (μg/ml)
P. falciparum0.010
(0.0080–0.013)		0.010
(0.0079–0.014)		0.032
(0.026–0.040)
P. vivax0.020
(0.017–0.024)		ND0.11 (0.081–0.15)
P. cynomolgi0.0050
(0.0042–0.0058)		NDND
Human~413.7 (2.6–4.8)>43
Mouse1.1 (1.2–1.5)0.10 (0.082–0.12)4.5 (3.1–6.9)
Rat0.82 (0.63–1.1)0.082 (0.069–0.099)1.6 (1.2–2.0)
Dog11 (8.8–12)0.56 (0.48–0.65)25 (21–29)
Rabbit>41ND>43
Pig>41NDND
Monkey>41NDND