Data represent mean of three technical replicates with 95% confidence intervals for the fit shown in parentheses. Primary data are provided in table S19. ND, not determined.
Compound | DSM265 | DSM430 | DSM450 |
DHODH | IC50 (μg/ml) | ||
P. falciparum | 0.010 (0.0080–0.013) | 0.010 (0.0079–0.014) | 0.032 (0.026–0.040) |
P. vivax | 0.020 (0.017–0.024) | ND | 0.11 (0.081–0.15) |
P. cynomolgi | 0.0050 (0.0042–0.0058) | ND | ND |
Human | ~41 | 3.7 (2.6–4.8) | >43 |
Mouse | 1.1 (1.2–1.5) | 0.10 (0.082–0.12) | 4.5 (3.1–6.9) |
Rat | 0.82 (0.63–1.1) | 0.082 (0.069–0.099) | 1.6 (1.2–2.0) |
Dog | 11 (8.8–12) | 0.56 (0.48–0.65) | 25 (21–29) |
Rabbit | >41 | ND | >43 |
Pig | >41 | ND | ND |
Monkey | >41 | ND | ND |