Table 1. Anti-EBOV activity and cytotoxicity of active compounds.

Parentheses indicate the SE for IC50 calculations. Table summarizes data shown in Fig. 2 and 3 and figs. S3 to S6. %I, maximum percent inhibition based on the curve fit; IC50, drug concentration in μM at which 50% inhibition of viral infection or host viability (without virus) was observed.

Drug nameVero E6HepG2
IC50 eGFP-EBOV
μM (SE)
%I eGFP-EBOVIC50 Host
μM (SE)
%I HostIC50 eGFP-EBOV
μM (SE)
%I eGFP-EBOVIC50 Host
μM (SE)
%I Host
Aripiprazole8.1 (0.42)86.720.73.76 (0.18)94.719.4 (1.61)82
Astemizole6.17 (1.34)96.537.91.37 (0.038)91.411.1 (0.055)99.6
Atovaquone0.437 (0.016)73.935.45.713.62
Azacitidine8.97 (2.6)74.727.910.3 (1.00)89.933.1
Benztropine8.07 (0)89.121.02.82 (0.13)93.918.1
Bepridil5.08 (0.38)9721.13.21 (0.15)91.249.3
Clemastine5.44 (0.32)95.839.80.652 (0.037)93.343.7
Clomiphene*2.42 (0.045)96.426.20.755 (0.046)92.015 (1.28)92
Clomipramine11.4 (0.15)96.121.12.57 (0.16)89.923.5
Dasatinib16.5 (4.6)64.235.64.23 (0.20)94.125.8 (0.80)71.3
Efavirenz10.7 (2.0)63.97.3813.5 (2.07)869.64
Flupentixol5.78 (0.20)95.941.91.59 (0.25)74.516.5
Fluphenazine5.54 (0.19)96.846.43.05 (1.68)9230
Hycanthone10.9 (0.85)96.842.95.96 (0.39)96.216.6 (0.82)62.9
Lomerizine11.4 (1.8)89.919.72.42 (0.12)91.843.9
Maprotiline9.63 (0.01)98.626.32.86 (0.15)92.641.3
Mycophenolate mofetil43.83.270.29 (0.15)88.617.6
Paroxetine7.45 (0.41)9639.91.38 (0.076)9223.6 (0.18)94.8
Pimozide3.12 (0.11)96.820.31.67 (0.044)9118.9 (0.18)99.4
Piperacetazine12.3 (0.85)96.223.13.3 (0.16)95.428.8
Prochlorperazine5.96 (0.42)96.342.83.59 (0.19)94.727.3
Quinacrine5.71 (0.61)92.323.6 (8.5)63.41.03 (0.052)86.212.9 (1.54)98.6
Sertraline3.13 (0.24)96.229.41.44 (0.057)9518 (0.53)54.4
Simvastatin44.6 (0.79)55.728.535.311.8
Strophanthin0.0346 (0.020)74.328.80.0207 (0.0014)86.80.0569 (0.00047)68.4
Teicoplanin7.28 (0.46)84.62.722.43 (0.16)772.33
Terconazole8.26 (0.32)96.633.22.38 (0.068)91.836.5
Thioridazine6.24 (0.79)95.410.2 (9.06)93.12.06 (0.12)93.421.6 (0.78)99.4
Toremifene*0.162 (0.048)93.511.40.026 (0.0013)94.95.43
Vinorelbine25.627.90.858 (0.034)78.832.9

*EBOV antiviral activity also described by Johansen et al. (11).

†EBOV antiviral activity also described by Shoemaker et al. (14).