Table 4. Pharmacokinetic parameters for select amSPCs.

Parameters are expressed as mean. Values in parentheses indicate %CV. t1/2, half-life for metabolic degradation; T1/2, Pharmacokinetic half-life; Vd, volume of distribution; CL, clearance; fe, fraction excreted unchanged in urine.

CompoundProtein bindingMicrosomal stabilityIntravenous pharmacokinetics (dose, 10 mg/kg)
%BoundT1/2 (hours)t1/2 (hours)*Vd (liters/kg)CL (liters hour−1 kg−1)fe
SPC13.0 (7.5)6.43 (0.13)0.75 (49.3)0.76 (45.2)0.60 (11.5)0.55 (27.0)
143.0 (1.7)6.80 (0.56)1.12 (14.2)0.64 (39.1)0.56 (23.0)0.82 (12.4)
362.6 (8.8)28.8 (2.19)1.99 (11.9)1.13 (32.7)0.53 (22.2)0.22 (28.1)
457.6 (11.9)23.1 (1.64)1.74 (2.8)1.45 (12.7)0.58 (5.4)0.58 (4.7)

*t1/2 is based on decline of plasma concentration in the therapeutically relevant concentration range.

†Spectinomycin values are from (31) and included for comparison.