Table 2. Summary of in silico randomized clinical trials in severe blunt trauma.

Simulated clinical trials were carried out as described in the Materials and Methods. Percent survival was evaluated at 30 days of simulated time.

InterventionAverage recovery time (days)Survivors (%)
Placebo6.0889.7
IL-1β neutralization6.0189.9*
IL-6 neutralization5.8690.4*
TNF-α neutralization8.7579.0*

*P < 0.005 versus placebo.