Table 2. Synergistic antiviral effect of CCZ in combination with anti-HCV drugs.

The level of synergy was defined in MacSynergy as follows: ++, moderate synergy (5 ≤ log volume < 9); +++, strong synergy (log volume ≥ 9). Combination indices (CI) are means ± SEM from combinations of the tested drug with (S)-CCZ at or near their EC50 values when tested alone (n ≥ 6). The level of synergy was defined by CalcuSyn as follows: ++, moderate synergy (0.7 ≤ CI < 0.85); +++, synergy (0.3 ≤ CI < 0.7).

ProgramParameterRibavirinIFN-αTelaprevirBoceprevirSofosbuvirDaclatasvirCyclosporin A
MacSynergyLog volume++++++++++++++++++++
CalcuSynCI value0.630 ± 0.1060.609 ± 0.1280.426 ± 0.1380.691 ± 0.1140.362 ± 0.0750.427 ± 0.1420.727 ± 0.187
Synergy volume+++++++++++++++++++++