Table 2. Cell killing activity of small-molecule BCL-2 family inhibitors.

SCLC and AML cell lines were incubated with increasing concentrations of navitoclax, venetoclax, or A-1155463 for 48 hours before assessing cell viability. Cell killing EC50 values are listed for each compound against the cell lines examined.

Cell typeCell lineCellTiter-Glo cell viability assay
Navitoclax
EC50 (μM)
Venetoclax
EC50 (μM)
A-1155463
EC50 (μM)
SCLCNCI-H8890.0530.0156.310
NCI-H2110.1000.3301.350
NCI-H1870.0370.8500.180
NCI-H3450.3001.200>10.000
NCI-H4460.8502.4000.200
NCI-H10480.9002.700>10.000
NCI-H690.1803.8603.200
NCI-H8470.1403.9000.003
NCI-H14170.1004.1000.007
DMS790.4404.6201.440
NCI-H18360.2605.0000.015
AMLGDM-10.0110.1001.170
EOL-10.0110.1002.250
MOLM-130.0300.100>5.000
HL-600.0400.100>5.000
MV4-110.0400.100>5.000
ML-20.0500.100>5.000
SIG-M50.0110.100>5.000
OCI-AML20.0110.100>5.000
MOLM-160.1200.040>5.000
OCI-AML50.1800.110>5.000
THP-10.4500.820>5.000
Kasumi-10.0301.0000.011
KG-10.1101.200>5.000
HNT-340.0301.7000.680
PL-210.1901.810>5.000
SKM-10.2402.530>5.000
UKE-10.0503.0600.490
SET-20.0603.3300.080
HEL0.0703.3700.120
OCI-M20.1604.0500.100
OCI-M10.410>5.0000.230
OCI-AML3>5.000>5.000>5.000
NOMO-1>5.000>5.000>5.000
ME-1>5.000>5.000>5.000