Table 2. Mathematical model parameter estimates.
ParameterDescriptionMedian estimate
(95% CI)*
Abdomen model
δwMelDose-response intercept for wMel-infected
mosquitoes
−1.12 (−3.22, 0.33)
θDENV1Infectious dose parameter for DENV15.90 (4.53, 6.58)
θDENV2Infectious dose parameter for DENV26.78 (5.88, 7.66)
θDENV3Infectious dose parameter for DENV38.41 (7.17, 10.29)
θDENV4Infectious dose parameter for DENV49.50 (8.34, 12.27)
γDose response shape parameter2.88 (1.66, 3.97)
ρabdomenOverdispersion parameter for abdomen model0.46 (0.38, 0.53)
Saliva modelBaselineAlternative
εwMelScaling of infectious dose parameters for
wMel-infected versus wild-type mosquitoes
3.41 (0.66, 11.2)Fixed at 1
κPower on infectivity growth with time3.80 (1.99, 6.59)3.40 (2.02, 5.04)
βWTTimescale of infectivity saturation in saliva
of wild-type mosquitoes
12.3 (9.5, 30.8)11.6 (8.7, 19.6)
βwMelTimescale of infectivity saturation in saliva
of wMel-infected mosquitoes
12.8 (7.3, 32.5)20.7 (15.4, 40.9)
φDENV1Infectious dose parameter for DENV10.52 (0.13, 0.81)0.60 (0.30, 0.97)
φDENV2Infectious dose parameter for DENV21.57 (0.37, 2.99)1.79 (0.80, 3.44)
φDENV3Infectious dose parameter for DENV30.94 (0.23, 2.15)1.11 (0.46, 2.33)
φDENV4Infectious dose parameter for DENV40.99 (0.24, 1.95)1.13 (0.50, 2.32)
ρsalivaOverdispersion parameter for abdomen model0.19 (0.13, 0.27)0.19 (0.13, 0.27)

*Median estimates and 95% CIs of parameters of the mathematical models (Eqs. 3 and 4) used to fit the abdomen and saliva infection data on wMel-infected and wild-type mosquitoes are shown. Time unit is days. †For the saliva model, estimates are shown for the best-fitting baseline model and an alternative model where the phenotypic effect of wMel infection is forced to act on the parameter β, determining EIP.