Table 3. PK of HPßCD after IC or IV administration in normal control cats.

NC, not calculated due to below detectable concentrations for some samples.

AnalyteRoute of
administration
DoseMatrixC0
(μg/ml)
AUC0-∞
(μg·hour/ml)
AUC0-24h
(μg·hour/ml)
t½
(hour)
CL/F
(ml/hour·kg)
Vdss
(ml/kg)
HPβCD (Sigma)IC120 mgCSF11,64528,6140.7–2.6
HPβCD (Kleptose)IC30 mgCSF15,40023,30023,1003.221.294.14
HPβCD (Kleptose)IV1000 mg/kgCSF13.1NC346NCNCNC
HPβCD (Kleptose)IV1000 mg/kgPlasma3,7604,6606,7701.11215336