Unselected DCM cohort. Values are means ± SD. Measurements are indexed to body surface area where indicated. LV, left ventricle; RV, right ventricle; EDVi/ESVi, indexed end-diastolic/systolic volume; SVi, indexed stroke volume; EF, ejection fraction; LVMi, indexed LV mass; WTi, indexed wall thickness; VT, ventricular tachycardia; NYHA, New York Heart Association functional class. Groups were compared using Wilcoxon-Mann-Whitney test for continuous variables, and Fisher’s exact test for categorical. P values not corrected for multiple testing, as variables were not independent.
| CMR and clinical data | TTNtv-negative (n = 277) | TTNtv-positive (n = 42) | P | |
| LV | EDVi | 136 ± 38 | 137 ± 34.1 | 0.677 |
| ESVi | 87.5 ± 39.1 | 93.7 ± 36.4 | 0.205 | |
| SVi | 48.2 ± 12.9 | 43.4 ± 14.1 | 0.041 | |
| EF | 37.5 ± 12.2 | 33.3 ± 13.3 | 0.047 | |
| RV | EDVi | 89.4 ± 24.7 | 89.6 ± 26.1 | 0.972 |
| ESVi | 45.2 ± 22.3 | 50.4 ± 25.9 | 0.234 | |
| SVi | 44.4 ± 12.6 | 39.2 ± 15.8 | 0.031 | |
| EF | 51.6 ± 14.1 | 45.2 ± 16 | 0.036 | |
| LVMi | 95.4 ± 27.6 | 87.1 ± 18.3 | 0.106 | |
| Lateral WTi | 3.13 ± 0.73 | 2.77 ± 0.713 | 0.003 | |
| Midwall fibrosis | 94/270 (35%) | 13/41 (32%) | 0.869 | |
| Age at diagnosis (years) | 53.4 ± 13.4 | 49.3 ± 13.7 | 0.115 | |
| NYHA status 1/2/3/4 | 116/104/36/1 | 19/16/4/1 | 0.692 | |
| Sustained VT | 20/97 (21%) | 9/14 (64%) | 0.001 | |
| Conduction disease | 82/227 (36%) | 8/36 (22%) | 0.130 | |
| Family history of DCM | 24/218 (11%) | 9/37 (24%) | 0.034 | |