Table 2. Clinical characteristics of DCM patients with and without TTNtv.

Unselected DCM cohort. Values are means ± SD. Measurements are indexed to body surface area where indicated. LV, left ventricle; RV, right ventricle; EDVi/ESVi, indexed end-diastolic/systolic volume; SVi, indexed stroke volume; EF, ejection fraction; LVMi, indexed LV mass; WTi, indexed wall thickness; VT, ventricular tachycardia; NYHA, New York Heart Association functional class. Groups were compared using Wilcoxon-Mann-Whitney test for continuous variables, and Fisher’s exact test for categorical. P values not corrected for multiple testing, as variables were not independent.

CMR and clinical dataTTNtv-negative (n = 277)TTNtv-positive (n = 42)P
LVEDVi136 ± 38137 ± 34.10.677
ESVi87.5 ± 39.193.7 ± 36.40.205
SVi48.2 ± 12.943.4 ± 14.10.041
EF37.5 ± 12.233.3 ± 13.30.047
RVEDVi89.4 ± 24.789.6 ± 26.10.972
ESVi45.2 ± 22.350.4 ± 25.90.234
SVi44.4 ± 12.639.2 ± 15.80.031
EF51.6 ± 14.145.2 ± 160.036
LVMi95.4 ± 27.687.1 ± 18.30.106
Lateral WTi3.13 ± 0.732.77 ± 0.7130.003
Midwall fibrosis94/270 (35%)13/41 (32%)0.869
Age at diagnosis (years)53.4 ± 13.449.3 ± 13.70.115
NYHA status 1/2/3/4116/104/36/119/16/4/10.692
Sustained VT20/97 (21%)9/14 (64%)0.001
Conduction disease82/227 (36%)8/36 (22%)0.130
Family history of DCM24/218 (11%)9/37 (24%)0.034