Table 1. Protection against lethal P. aeruginosa pneumonia.

Summary of lethal pneumonia survival studies completed for the indicated mAbs against P. aeruginosa strains 6206 and 6077. Mice were treated prophylactically with antibody 24 hours before infection. No survival was observed in mice treated with the isotype control IgG against either strain. Differences in survival for BiS4αPa versus the anti-Psl/anti-PcrV mAb mixture at 0.5 mpk for 6206 and 0.02 mpk for 6077 were evaluated by the log-rank test (*P < 0.0001). 6206: Results were compiled from 15 independent experiments; n is indicated in parentheses. 6077: Results were compiled from 11 independent experiments; n is indicated in parentheses. For the anti-Psl and anti-PcrV mAb mixture, the indicated mpk is for each mAb. Parentheses indicate total number of animals analyzed at each antibody dosage. nd, not determined.

Antibody percent protection
Strain 6206Dose (mpk)Anti-PslAnti-PcrVBiS2αPaBiS3αPaBiS4αPaAnti-Psl + anti-PcrV
50 (10)80 (10)70 (10)40 (20)100 (60)100 (10)
10 (10)20 (10)10 (10)10 (20)88 (60)78 (40)
0.5nd10 (10)0 (10)0 (20)*60 (60)15 (40)
Strain 6077Dose (mpk)Anti-PslAnti-PcrVBiS4αPaAnti-Psl + anti-PcrV
0.564 (24)100 (16)100 (10)100 (10)
0.260 (24)88 (24)96 (26)100 (18)
0.076.3 (16)83 (24)92 (26)69 (18)
0.02nd13 (16)*50 (16)0 (8)