Table 1 Characteristics of the dogs in the comparative canine study.
Case IDSex*BreedAge
(years)
Body
weight
(kg)
Tumor
type
GradeLocationLongest
diameter§
(mm)
Previous
treatment||
Number of
C. novyi-NT
treatment
cycles
01-R02FNBorder
Collie
14.321.7STS—PNSTIILeft flank43None4
04-R01MNGolden
Retriever
7.934.0STS—PNSTIIRight maxilla15Surgical4
04-R02MIGolden
Retriever
12.038.8STS—PNSTIRight lateral
metacarpus
46Surgical4
04-R03MNBoxer9.629.4STS—PNSTILeft medial
antebrachium
56None3TR
04-R04FNSt. Bernard11.731.0OSAcIIIRight proximal
humerus
NDSurgical1AE
04-R05MNShetland
Sheepdog
14.013.4STS—RMSIIIRight cranial
antebrachium
45Surgical and
C. novyi-NT spores IV
4
04-R06FNLabrador
Retriever
11.624.3MCTIIIRight hindlimb
digit III
23None4
04-R08FNShepherd7.228.9STS—PNSTIRight medial
hindlimb paw
65Surgical3PD
10-R01MNGolden
Retriever
13.733.6OMMIIILeft mandible27Surgical2AE
10-R02MNPit Bull
Terrier
10.043.6STS—PNSTIRight flank53Surgical4
11-R01MNMaltese11.18.1STS—PNSTIILeft pinna28Surgical1TR
11-R02FNLabrador
Retriever
12.230.3STS—PNSTIILeft stifle43None3IV
11-R04MNHusky10.344.3STS—FBSIRight forelimb paw29None4
16-R02MNLabrador
Retriever
9.836.8STS—MXSILeft lateral thigh91Surgical4
16-R03FNShepherd10.820.8STS—SCSILeft forelimb paw53Surgical4
26-R01MNLabrador
Retriever
7.930.8STS—RMSIIRight forelimb paw24None4

*FN, female neutered; MN, male neutered; MI, male intact.

STS, soft tissue sarcoma; PNST, peripheral nerve sheath tumor; OSAc, chondroblastic osteosarcoma; RMS, rhabdomyosarcoma; MCT, mast cell tumor; OMM, oral malignant melamona; FBS, fibrosarcoma; MXS, myxosarcoma; SCS, synovial cell sarcoma.

Grading based on published criteria (4346): I, low grade; II, intermediate grade; III, high grade; NA, not assessed.

§Longest diameter at time of first C. novyi-NT injection (day 0). ND, unmeasurable because of location.

||04-R05, previous C. novyi-NT therapy with a single intravenous injection of 1 × 107 spores/m2 437 days before the first intratumoral injection of C. novyi-NT spores.

A treatment cycle consisted of one intratumoral injection of 1 × 108 C. novyi-NT spores. Dogs received up to four cycles, typically 1 week apart. Reason for receiving fewer than four treatment cycles given in superscript: TR, tumor response; AE, adverse event; PD, progressive disease; IV, fourth dose given intravenously.