Table 3. Analysis of lineage tree founder cells by compartment.

P values are provided for testing the hypothesis that founders are multicompartment (CNS/CLN) versus single compartment (CNS or CLN), as well as CNS versus CLN.

SubjectCompartmentTotal
nodes,
% (n)
Percentage of
lineages (n)
P
FoundersUnmutated
founders
M2CNS/CLN2.7 (32)18.7 (6)3.1 (1)0.00324
CNS or CLN97.3 (1,133)81.3 (26)00.99250
CNS9.7 (113)12.5 (4)00.85100
CLN87.6 (1,020)68.8 (22)00.14750
M3CNS/CLN3.5 (739)45.0 (139)0.3 (1)<0.0005
CNS or CLN96.5 (20,196)55.0 (170)0>0.9995
CNS19.3 (4,034)8.7 (27)0>0.9995
CLN77.2 (16,162)46.3 (143)0<0.0005
M5CNS/CLN3.7 (2,374)29.5 (425)7.1 (103)<0.0005
CNS or CLN96.3 (62,220)70.5 (1,017)1.2 (18)>0.9995
CNS2.4 (1,534)1.0 (15)0>0.9995
CLN93.9 (60,686)69.5 (1,002)1.2 (18)<0.0005
CombinedCNS/CLN<3.74 × 10−5
CNS or CLN>0.9999
CNS>0.9999
CLN<4.34 × 10−5