Table 1 Rationale for registration of CTs.

The Ottawa statement is provided in (21). All rationales listed are applicable to OSs.

Ethical
• Respect the investigator-participant covenant to contribute to biomedical knowledge by making trial methods and results public
• Provide global open access to information
• Reduce unnecessary duplication of invested research resources through awareness of existing trials
• Assure accountability with regard to global standards for ethical research
• Enable monitoring of adherence to ethical principles and process
Scientific
• Increase the reliability and availability of evidence on which health care decisions are based
• Improve trial participation
• Increase opportunities for collaboration
• Ensure transparency of trial design and methods
• Provide open review of protocols to improve trial quality and refine methods
• Provide means for identification and prevention of biased underreporting or over-reporting of research
• Accelerate knowledge creation