Table 1 Breast cancer cell line information.

Twenty-five breast cancer cell lines are listed in increasing order of sensitivity to BYL719. HER2 and MYC amplification, as well as PIK3CA, PTEN, TP53, TSC2, and NRAS mutational status, is reported (TCGA and Cosmic database).

Cell linePIK3CAPTENHER2TP53TSC2MYCHRAS
MDA-MB-
231
WTR280K
HCC1428WT
CAMA-1WTF278fs,
D92H
R280TDel
MDA-MB-
468
WTV85_splice
CAL51E542KE288fs,
T321fs
ZR-75-1WTL108RE162K
UACC812N345KAmp
JIMT-1C420RAmpR248W
MFM223H1047Rc.395A>G,
K132R
Amp
CAL148D350N,
H1047R
I253N,
Q298*
E224K
BT20P539R,
H1047R
K132Q
OCUB-FH1047R
HCC1954H1047RAmpY163CDelAmp
SUM190PTH1047RAmp
MCF7E545K
BT474K111NAmpE285K
KPL-1E545K
UACC893H1047RAmpR342*
EFM19H1047LAmpH193R
SUM185PEH1047R
MDA453H1047RE307KAmp
HCC202E545K,
L866F
AmpT284fs
MDA-MB-
361
E545K,
K567R
AmpE56*
BT483E542KM246I
T47DH1047RL194F

*Nonsense mutation.