Table 1

STX209 concentrations in mouse plasma and brain. The pharmacokinetics of STX209 in plasma and brain after inraperitoneal injection or administration in the drinking water.

Intraperitoneal injectionDrinking water
Dose (mg/kg per day)Cmax (ng/ml)tmax (hours)AUClast (ng hour/ml)Concentration (mg/ml)Cmax (ng/ml)AUClast (ng hour/ml)
PlasmaPlasma
18010.59870.05274902
325200.2526710.14181393
643470.2548460.522514502
Dose (mg/kg per day)Cmax (ng/mg)tmax (hours)AUClast (ng hour/mg)Concentration (mg/ml)Cmax (ng/mg)AUClast (ng hour/mg)
BrainBrain
10.0250.50.057
30.0550.50.162
60.1330.50.2230.50.1810.467