Table 4

VHL mutations in patient tumors and tumorgrafts. n/a, not assessed; TG, tumorgrafts of increasing passages.

IDVHL mutation
(tumor)
Retained mutations
TG(I)TG(II)TG(III)
TG22c.472C>G,p.L158V+n/an/a
TG127c.232_233delAA++n/a
TG142c.525_533delCAGGAGACT++n/a
TG144c.506T>C,p.L169P+++
TG166c.224_226delTCT+++
TG183c.414_421delATCTCTCA++n/a