Table 1

Patient demographics and characteristics of tumors implanted. Data in bold indicate tumorgraft lines giving rise to stable lines (TG ≥ 2). TG, tumorgraft; Mut, mutation (germline and somatic); wt, wild type; Sarc., sarcomatoid differentiation; Grade, Fuhrman nuclear grade; pT, pathologic T stage; pN, pathologic N stage; TG-0, histologically confirmed tumor in recipient mouse cohort; TG ≥ 2, histologically confirmed tumor passaged more than twice in mice; n/a, not applicable or assessed; Uni, unifocal; Multi, multifocal; M, male; F, female; Y, yes; N, no.

T (ID)Age (years)SexVHLSourceHistologySarc.GradeFocalitySize (cm)pTpNTG-0TG ≥ 2
111469MMutPrimaryClear cellY4Uni10.030YN
211565FMutPrimaryClear cellN4Uni8.02×YY
311666MMutPrimaryClear cellYn/aUni17.040NN
411761Mn/aPrimaryPapillaryN3Uni4.01×NN
511865FMutPrimaryClear cellN2Uni2.51×NN
611979Fn/aPrimaryClear cellN3Uni5.71×NN
712062Mn/aPrimaryClear cellN1Uni2.91×NN
812178Fn/aPrimaryPapillaryN2Uni3.01×YY
912268Fn/aPrimaryChromophobeN3Uni25.030NN
1012356Mn/aPrimaryPapillaryN3Multi3.11×NN
1112463Mn/aPrimaryClear cellN2Uni3.21×NN
1212562FMutPrimaryClear cellN2Uni4.51×YN
1312653MMutPrimaryClear cellN2Uni4.51×NN
1412735MMutPrimaryClear cellN3Uni6.23×YY
1512871MMutPrimaryClear cellN3Uni4.01×NN
1612967Mn/aMetastasisClear cellNn/an/a4.0n/an/aNN
1713061FMutPrimaryClear cellN2Uni6.03×NN
1813149FMutPrimaryClear cellN2Uni3.010YN
1913257Mn/aPrimaryPapillaryN3Uni7.920NN
2013358FMutPrimaryClear cellN2Uni7.230NN
2113459Fn/aPrimaryClear cellN2Uni1.11×NN
2213563Mn/aPrimaryClear cellN1Uni2.91×NN
2313673FwtPrimaryClear cellN2Uni8.52×NN
2413777Mn/aPrimaryPapillaryN3Uni2.21×YN
2513868Fn/aPrimaryChromophobeN2Uni5.41×NN
2613966Mn/aPrimaryPapillaryN2Uni8.52×YN
2714052Mn/aPrimaryPapillaryN3Multi6.21×NN
2814151Mn/aPrimaryChromophobeN3Uni5.71×NN
2914256FMutPrimaryClear cellN3Uni8.63×YY
3014374FwtPrimaryClear cellY4Uni11.04×YY
3114471MMutPrimaryClear cellN4Uni7.521YY*
3214555FMutPrimaryClear cellN2Uni7.01×YN
3314660FMutPrimaryClear cellN2Uni4.01×NN
3414759Mn/aPrimaryLiposarcoman/an/an/a14.0n/an/aNN
3514864Mn/aPrimaryPapillaryN2Uni6.51×NN
3614956MwtPrimaryClear cellY4Uni11.530NN
3715050FMutPrimaryClear cellN3Uni6.73×YN
3815174MMutPrimaryClear cellN2Uni7.72×YN
3915225Fn/aMetastasisPapillaryNn/an/a4.5n/an/aYY
4015362MMutPrimaryClear cellN2Uni3.51×YN
4115462Mn/aPrimaryOncocytomaNn/an/a4.0n/an/aNN
4215564MMutPrimaryClear cellY4Uni10.030NN
4315665Fn/aPrimaryPapillaryN3Uni11.520YY
4415772FMutPrimaryClear cellN2Uni5.21×NN
4515882FMutPrimaryClear cellY3Multi12.73×YY
4615924Mn/aPrimaryClear cellN2Multi3.01×NN
4716062MMutPrimaryClear cellN2Uni4.21×NN
4816136MMutPrimaryClear cellN2Uni8.42×YN
4916256MMutPrimaryClear cellN3Uni7.23×YN
5016352MMutPrimaryClear cellY4Uni4.510NN
5116475MwtPrimaryClear cellY4Uni11.34×YY
5216542MMutMetastasisClear cellN3n/a1.3n/an/aYY
5316656MMutPrimaryClear cellY4Uni9.031YY*
5416774Mn/aPrimaryClear cellN3Uni4.01×NN
5516853Mn/aPrimaryUnclassifiedY4Uni8.031YY
5616952Mn/aPrimaryUnclassifiedN4Uni5.541YY
5717062FMutPrimaryClear cellN4Uni8.030NN
5817162FMutPrimaryClear cellN2Uni4.21×NN
5917261Fn/aPrimaryCystic nephromaNn/an/a10.7n/an/aNN
6017350MMutPrimaryClear cellN3Multi12.03×YN
6117470Fn/aPrimaryOncocytomaNn/an/a3.5n/an/aNN
6217562FMutPrimaryClear cellN4Uni11.520NN
6317671Mn/aPrimaryPapillaryN3Uni11.531NN
6417756Fn/aPrimaryClear cellN2Uni3.21×YN
6517851Mn/aPrimaryPapillaryN2Uni5.51×YN
6617960Mn/aPrimaryClear cellN3Uni7.52×NN
6718056MMutMetastasisClear cellNn/an/a3.5n/an/aYY
6818171Mn/aPrimaryClear cellN3Uni12.030NN
6918265Mn/aPrimaryClear cellN3Uni6.031NN
7018356MMutPrimaryClear cellN2Uni4.31×NN
7118449MMutPrimaryClear cellN3Uni10.030NN
7218578Fn/aPrimaryOncocytomaNn/an/a6.0n/an/aYN
7318651Mn/aPrimaryPapillaryN3Uni9.02×NN
7418745Mn/aPrimaryUnclassifiedN3Multi18.031NN
7518854Fn/aPrimaryClear cellN2Uni2.61×NN
7618976Mn/aPrimaryOncocytomaNn/an/a4.0n/an/aNN
7719063Mn/aPrimaryPapillaryN3Uni7.52×NN
7819183MMutPrimaryClear cellN3Uni9.63×YN
7919263FMutPrimaryClear cellN2Uni6.810YN
8019370MMutPrimaryClear cellN3Uni12.020NN
8119456FMutPrimaryClear cellN3Uni4.53×NN
8219571FMutPrimaryClear cellN3Uni5.33×NN
8319657Fn/aPrimaryChromophobeN2Uni11.520NN
8419760MMutPrimaryClear cellN3Uni8.52×NN
8519851Fn/aPrimaryClear cellN2Uni4.510NN
8619950MwtPrimaryClear cellN3Uni13.030YN
8720059Fn/aPrimaryOncocytomaNn/an/a3.5n/an/aNN
8820160Mn/aPrimaryClear cellN2Multi5.710NN
8920266MMutPrimaryClear cellN3Uni13.330NN
9020365Fn/aPrimaryClear cellN2Uni3.51×YN
9120461FwtPrimaryClear cellN2Uni3.51×NN
9220547FMutPrimaryClear cellN3Uni5.11×NN
9320672Mn/aMetastasisClear cellNn/an/a1.1n/an/aYY
9420749Fn/aPrimaryAngiomyolipomaNn/an/a4.5n/an/aNN

*Tumor noted to induce hypercalcemia in tumorgraft.