Table 1

Definition of terms.

GenometypeA set of genomes that confer a specific genetic risk
for a given disease
Genometype
genetic risk (r)
The genetic risk conferred by a given genometype
Genometype
frequency (f)
The frequency of a given genometype in the general
population
ThresholdMinimum risk for a given disease considered to be
clinically meaningful
Heritability (HER)Proportion of phenotypic variance associated with
genetic factors
Cohort risk (CR)Risk of disease in the relevant twin cohort
Nongenetic
risk (e)
Proportion of cohort risk due to nongenetic factors
Total riskSum of genetic risk conferred by a given genometype
plus nongenetic risk
Relative riskRatio of total risk associated with a given genometype
to cohort risk