Table 2

Quantification of selected proteins measured by SRM in plasma of OC patients and patients with BOTs. Statistical analysis was performed using a linear mixed-effects model implemented in SRMstats (27). The proteins were selected because they either are part of the OVA1 biomarker panel (OVA1), have been proposed as biomarker candidates for OC (literature), or functionally interact with epigenetically silenced or mutated genes in OC (network).

ProteinGene symbolFold changePSignificantSource (regulation)Publication
AACTSERPINA31.547.18 × 10−10YesLiterature (up), network(7375)
APOA1APOA10.860.0016YesOVA1 (down)(53, 55, 56)
APOEAPOE0.831.39 × 10−4YesLiterature (up)(75)
B2MGB2M1.192.51 × 10−4YesOVA1 (up)(53, 55, 56)
C1RC1R1.161.19 × 10−5YesNetwork
CFABCFB1.298.22 × 10−6YesNetwork
CO5C51.191.27 × 10−5YesNetwork
CO6C61.110.0026YesNetwork
CO7C71.223.55 × 10−4YesNetwork
GELSGSN0.771.39 × 10−4YesNetwork
HPTHP1.670YesLiterature (up), network(56, 75)
IC1SERPING11.180.0050YesLiterature (up), network(73)
ITIH4ITIH41.181.77 × 10−5YesLiterature (up)(55, 73, 74)
RET4RBP40.764.11 × 10−7YesNetwork
SHBGSHBG1.476.96 × 10−11YesNetwork
TETNCLEC3B0.783.02 × 10−8YesLiterature (down)(76)
THBGSERPINA71.201.24 × 10−4YesNetwork
TRFETF0.842.79 × 10−8YesOVA1 (down)(53, 55, 56)
TTHYTTR0.702.73 × 10−8YesOVA1 (down)(53, 55, 56)
A2MGA2M0.890.0605NoNetwork
APOALPA1.330.0605NoLiterature (up)(73)
APOBAPOB1.040.4771NoLiterature (down)(77)
C1QAC1QA0.980.6961NoNetwork
C1QBC1QB1.080.0362NoLiterature (up), network(73)
C1QCC1QC0.970.6555NoNetwork
CADH5CDH51.010.8670NoNetwork
CLUSCLU0.950.0626NoLiterature (up)(74, 78, 79)
CO3C31.090.0163NoNetwork
CO4AC4A1.050.4255NoNetwork
FN1FN10.820.0181NoNetwork
IGF2IGF20.970.5384NoNetwork
PLMNPLG1.000.9690NoNetwork
THRBF21.000.9598NoNetwork
VTNCVTN1.030.4771NoLiterature (up), network(80)