Table 2

HSV-2 vaginal challenge results. Infections in DP mice resulting from vaginal challenge with HSV-2 30 min after drug administration. Statistical significance was determined using Fisher’s exact test, two-tailed distribution. N/A, not applicable.

GroupDrug form (concentration)VehicleNumber of miceNumber infectedPercent infectedP (versus ACVp-MPPs)
2Soluble ACVp (1 mg/ml)PBS252184.00.002
3Soluble ACVp (10 mg/ml)PBS1006262.00.10
4Soluble ACVp (10 mg/ml)Water755269.30.02
5ACVp-MPPs (1 mg/ml)Water452146.7N/A