Table 2

Correlation of B7-H1 expression by melanocytes with the presence of immune cell infiltration.

HistologyTotalNumber of cases/total cases (%)P*
B7-H1+†B7-H1
TIL+‡TILTIL+TIL
Benign nevi4014/14 (100)0/14 (0)4/26 (15)22/26 (85)<0.0001
Primary melanomas (in situ or invasive)5419/19 (100)0/19 (0)15/35 (43)20/35 (57)<0.0001
Metastases5623/24 (96)1/24 (4)7/32 (22)25/32 (78)<0.0001
All15056/57 (98)1/57 (2)26/93 (28)67/93 (72)<0.0001

*Fisher’s exact test, two-sided, was conducted on the 2 × 2 matrix defined by B7-H1 (±) expression and TIL (±) for each lesion type.

†More than 5% melanocytes with membranous expression on IHC.

‡Including mild, moderate, and severe lymphocyte infiltrates and their associated histiocytes/macrophages.