Table 3

Average PK parameters for hPTH(1–34) from the microchip device compared to 2 × 20–μg and single 20-μg FORSTEO injections. Data are means ± SD. ND, not determined.

Drug, method of deliveryDose (μg)Number of samplesCmax (pg/ml)Tmax (min)AUC0–last (ng·min/ml)T1/2 (min)Reference
hPTH(1–34), implant4028405 ± 16145 ± 1144 ± 870 ± 20This study
FORSTEO, injection2 × 2014400 ± 19423 ± 1028 ± 953 ± 15This study
FORTEO, injection*4034460 (146–875)58 (40–91)46 (17–69)ND(21)
FORSTEO, injection2014192 ± 5522 ± 614 ± 455 ± 16This study
FORTEO, injection2022151 ± 5732 ± 1510 ± 490 ± 107(21)

*Range shown in parentheses.