Table 2

Results of PK parameters by patient. (A) Doses delivered by the implant (n = 4). (B) Doses delivered as 2 × 20–μg injections (n = 2). Data are means ± SD.

PatientCmax (ng/ml)Tmax (min)AUC (ng·min/ml)T1/2 (min)
A. Implant [hPTH(1–34)]
MC-0002538 ± 11151 ± 851 ± 251 ± 11
MC-0003249 ± 4956 ± 836 ± 489 ± 28
MC-0005598 ± 6732 ± 348 ± 448 ± 7
MC-0011353 ± 7941 ± 1436 ± 769 ± 4
MC-0012255 ± 1945 ± 1241 ± 191 ± 8
MC-0018575 ± 5139 ± 1057 ± 268 ± 5
MC-0020266 ± 4349 ± 840 ± 372 ± 12
B. Injection (FORSTEO)
MC-0002489 ± 12726 ± 626 ± 139 ± 13
MC-0003335 ± 3925 ± 724 ± 544 ± 5
MC-0005206 ± 9328 ± 2618 ± 164 ± 19
MC-0011255 ± 2321 ± 127 ± 977 ± 7
MC-0012476 ± 5623 ± 437 ± 161 ± 4
MC-0018770 ± 4311 ± 1741 ± 345 ± 2
MC-0020273 ± 527 ± 522 ± 149 ± 6