Table 2

Echocardiographic parameters of wild-type and Mecp2Null/Y mice at 2 to 3 months of age. Data are expressed as means ± SEM. HR, heart rate; bpm, beats per minute; EF, ejection fraction; FS, left ventricular fractional shortening; ESD, end-systolic diameter; EDD, end-diastolic diameter; IVSs/IVSd, intraventricular septal wall thickness in systole/diastole; LVPWs/LVPWd, left ventricular posterior wall thickness in systole/diastole.

WT (3 months)
(n = 8)
Mecp2Null/Y (3 months)
(n = 8)
HR (bpm)478.2 ± 39.7536.4 ± 57.1*
EF (%)65.2 ± 6.270.7 ± 5.9
FS (%)35.3 ± 4.639.5 ± 4.8
ESD (mm)2.5 ± 0.42.1 ± 0.3
EDD (mm)3.8 ± 0.33.5 ± 0.2
IVSs (mm)0.96 ± 0.060.95 ± 0.08
IVSd (mm)0.7 ± 0.10.8 ± 0.1
LVPWs (mm)1.09 ± 0.151.18 ± 0.09
LVPWd (mm)0.8 ± 0.10.8 ± 0.1

*P < 0.05 versus wild type.