Sensitivity, specificity, and accuracy of different protein markers (single or in combination).
Number | Marker | μNMR value | Sensitivity (%) | Specificity (%) | Accuracy (%) |
Single | MUC-1 | 0.25 | 66 | 83 | 68 |
EGFR | 0.20 | 64 | 83 | 66 | |
B7-H3 | 0.11 | 68 | 67 | 68 | |
HER2 | 0.24 | 64 | 100 | 68 | |
Ki-67 | 0.10 | 68 | 67 | 68 | |
EpCAM | 0.21 | 59 | 67 | 60 | |
Vimentin | 0.08 | 59 | 67 | 60 | |
CK18 | 0.06 | 73 | 50 | 70 | |
p53 | 0.38 | 41 | 83 | 46 | |
Dual | EpCAM + CK18 (unweighted) | 0.27 | 84 | 50 | 80 |
EpCAM + CK18 (weighted) | 0.65 | 73 | 67 | 72 | |
Triple | MUC-1 + HER2 + EGFR (weighted) | 1.23 | 95 | 67 | 92 |
Quad | MUC-1 + HER2 + EGFR + EpCAM (weighted) | 1.6 | 100 | 67 | 96 |