Table 2

Patients with lung tumors showing an NSCLC to SCLC transformation. ID number refers to the patient number in Table 1. Pre-, pretreatment; Post-, posttreatment/drug-resistant.

Age (years)GenderID no.BiopsyHistologySynaptophysinChromograninCD56Genotype
67Female22Pre-AdenocarcinomaL858R
Post-SCLC+++L858R
54Female23Pre-AdenocarcinomaWeak+Exon 19 deletion
Post-SCLCStrong+Exon 19 deletion
56Female24Pre-AdenocarcinomaL858R
Post-SCLC++L858R, PIK3CA
40Female25Pre-AdenocarcinomaExon 19 deletion
Post-SCLC+Exon 19 deletion
61Female26Pre-AdenocarcinomaL858R
Post-SCLC++L858R