Table 1.

Barriers to enrollment in clinical trials.

• Insufficient physician time/interest
• Lack of dedicated research staff
• Lack of equipoise in clinical trial design
• Increasing protocol eligibility requirements and protocol complexity
• Lack of reimbursement for physician management of patients in trials
• Off-label prescribing of drugs
• Lack of insurance coverage for patients participating in clinical trials
• Regulatory liability and burden
• Insufficient patient awareness/demand