Barriers to enrollment in clinical trials.
| • Insufficient physician time/interest |
| • Lack of dedicated research staff |
| • Lack of equipoise in clinical trial design |
| • Increasing protocol eligibility requirements and protocol complexity |
| • Lack of reimbursement for physician management of patients in trials |
| • Off-label prescribing of drugs |
| • Lack of insurance coverage for patients participating in clinical trials |
| • Regulatory liability and burden |
| • Insufficient patient awareness/demand |