Table 1. Illustrative examples of academic labs that are contributing to the drug discovery process.

IDs, infectious diseases; CVs, cardiovascular diseases.

InstitutionIllustrative disease focusAreas of basic research and drug discovery
Disease biology/gene discoveryChemical biology/pathwaysDisease target identificationDrug target identificationDrug target validationDevelopment of assays to screen compoundsHigh-throughput screeningIdentification of chemical hits and leadsLead testing in animal modelsSAR/lead optimizationPreclinical candidate identificationClinical candidate selectionDose range-finding toxicologyPhase IPhase IIPhase III
Broad InstituteAging, cancer, diabetes, IDs************
Burnham InstituteCancer, diabetes, obesity************
Cal TechAddiction*****
Case Western ReserveCancer***********
Columbia U.Cancer, CVs, neurological diseases, IDs*********
Duke U.Aging, cancer**************
Emory U.Cancer, IDs, inflammation************
Georgetown U.Cancer******
Harvard U.Cancer, CVs, NDDs************
Memorial Sloan-KetteringCancer**********
MITAging, cancer*****
Mt. SinaiCancer***********
Northwestern U.Cancer*****
Ohio State U.Cancer**************
Purdue U.Cancer*******
Rockefeller U.Cancer, obesity*****
Scripps InstituteCancer, CVs, immune diseases, IDs*********
Stanford U.Cancer, others**********
U. of ChicagoCancer******
U. of CincinnatiCancer, diabetes, obesity********
U. of ColoradoPain/general***
U. of GeorgiaCancer, IDs****
U. of KansasCancer*************
U. of MichiganAlzheimer’s disease, cancer, diabetes*******
U. of MinnesotaCancer***********
U. of North CarolinaCancer*****
U. of PensylvaniaCancer********
U. of PittsburghOrphan/neglected diseases**********
U. of Texas SouthwesternCVs, neurogenesis*******
U. of UtahCancer****
U. of WashingtonCancer****
U. of WisconsinIDs*******
UC BerkeleyAIDS, cancer, diabetes, IDs******
UC Los AngelesAging, diabetes, obesity*********
UC San DiegoPediatric diseases****
UC San FranciscoCancer, CVs, immune diseases, IDs, metabolic diseases, NDDs***************
UC Santa CruzCancer, viral***
Vanderbilt U.Cancer, obesity******
Washington U.Aging, cancer*****