Table 1. The GWAS potential.

GWAS* can reveal new therapeutic targets for complex diseases (8, 56, 57).

DiseaseTotal GWAS hitsGWAS hits associated with marketed drugsGWAS hits associated with drug effects§
Type 2 diabetes4468
Hyperlipidemia39210
Multiple sclerosis3652
Psoriasis2441

*Genome-wide association studies (GWAS) assume no knowledge of disease pathogenesis and provide a comprehensive approach to the discovery of common genetic risk factors. Many known drug targets and associated pathways appear on the list of GWAS hits for common diseases, suggesting that other GWAS hits likely represent “druggable” targets worthy of further investigation.Genetic variants strongly linked to disease susceptibility.Genetic variants that are primary targets of drugs currently marketed for the listed indication. §Genetic variants associated with cellular, pharmacokinetic, pharmacodynamic, or clinical variations in response to one or more drugs currently marketed for the listed indication.