Table 2

Blood and serum chemistry profiles of the AAV1-FS344–treated macaques. Hematology and serum chemistries were monitored throughout the study monthly after gene transfer with CMV-FS and MCK-FS. Data from 5 and 15 months are shown. The values are means ± SD (n = 3); there were no significant changes at any time. CK, creatine kinase; ALT, alanine aminotransferase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; GGT, γ-glutamyltranspeptidase.

MCK-FSCMV-FS
Baseline5 Months after injection15 Months after injectionBaseline5 Months after injection15 Months after injection
Hemoglobin (mg/dl)11.7 ± 1.212.3 ± 0.713.512.9 ± 0.912.9 ± 0.312.6
Leukocytes (103/mm3)9.4 ± 3.611.0 ± 1.87.513.2 ± 1.710.8 ± 2.815.5
Platelets (103/mm3)444.7 ± 78.6473.7 ± 101.5448.5475.3 ± 21.2470.0 ± 10.8432.0
CK (U/liter)282.3 ± 123.3103.3 ± 34.0261.0315.1 ± 436.8141.0
ALT (U/liter)29.7 ± 12.919.7 ± 2.131.528.7 ± 10.321.7 ± 4.629.5
AST (U/liter)35.3 ± 3.5134.7 ± 9.937.544.3 ± 11.431.7 ± 6.035.5
BUN (mg/dl)19.0 ± 1.012.3 ± 1.516.016.3 ± 4.916.0 ± 4.418.0
Creatinine (mg/dl)0.5 ± 0.10.8 ± 0.10.70.9 ± 0.20.9 ± 0.10.9
GGT (U/liter)72.0 ± 28.892.0 ± 38.777.577.0 ± 20.771.3 ± 18.275.0