Table 1

Metabolic pathways altered by diet in the humanized mouse gut microbiome. Based on a bootstrap analysis of gut microbiome data sets from humanized mice fed the LF/PP diet [7 to 35 dpc (days after colonization with a human fecal sample)] or the Western diet (29 to 35 dpc; confidence interval = 0.95, 10,000 samples; inclusion criterion, pathways must be found at ≥0.6% relative abundance in at least two samples).

KEGG pathways enriched on LF/PP dietCyanoamino acid metabolism
Glycosaminoglycan degradation
Glycosphingolipid biosynthesis—ganglioseries
N-glycan degradation
Nucleotide sugar metabolism
Other ion-coupled transporters
Pentose and glucuronate interconversions
Phenylpropanoid biosynthesis
Sphingolipid metabolism
Starch and sucrose metabolism
KEGG pathways enriched on Western dietABC transporters