RT Journal Article
SR Electronic
T1 Locoregional delivery of stem cell–based therapies
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP eaba4564
DO 10.1126/scitranslmed.aba4564
VO 12
IS 547
A1 Ng, Nathan Norton
A1 Thakor, Avnesh Sinh
YR 2020
UL http://stm.sciencemag.org/content/12/547/eaba4564.abstract
AB Interventional regenerative medicine (IRM) uses image-guided, minimally invasive procedures for the targeted delivery of stem cell–based therapies to regenerate, replace, or repair damaged organs. Although many cellular therapies have shown promise in the preclinical setting, clinical results have been suboptimal. Most intravenously delivered cells become trapped in the lungs and reticuloendothelial system, resulting in little therapy reaching target tissues. IRM aims to increase the efficacy of cell-based therapies by locoregional stem cell delivery via endovascular, endoluminal, or direct injection into tissues. This review highlights routes of delivery, disease states, and mechanisms of action involved in the targeted delivery of stem cells.