RT Journal Article
SR Electronic
T1 Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP eaap9630
DO 10.1126/scitranslmed.aap9630
VO 10
IS 436
A1 Chabannon, Christian
A1 Kuball, Jurgen
A1 Bondanza, Attilio
A1 Dazzi, Francesco
A1 Pedrazzoli, Paolo
A1 Toubert, Antoine
A1 Ruggeri, Annalisa
A1 Fleischhauer, Katharina
A1 Bonini, Chiara
YR 2018
UL http://stm.sciencemag.org/content/10/436/eaap9630.abstract
AB Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation.