RT Journal Article SR Electronic T1 Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies JF Science Translational Medicine FD American Association for the Advancement of Science SP eaap9630 DO 10.1126/scitranslmed.aap9630 VO 10 IS 436 A1 Chabannon, Christian A1 Kuball, Jurgen A1 Bondanza, Attilio A1 Dazzi, Francesco A1 Pedrazzoli, Paolo A1 Toubert, Antoine A1 Ruggeri, Annalisa A1 Fleischhauer, Katharina A1 Bonini, Chiara YR 2018 UL http://stm.sciencemag.org/content/10/436/eaap9630.abstract AB Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation.