PT  - JOURNAL ARTICLE
AU  - Chabannon, Christian
AU  - Kuball, Jurgen
AU  - Bondanza, Attilio
AU  - Dazzi, Francesco
AU  - Pedrazzoli, Paolo
AU  - Toubert, Antoine
AU  - Ruggeri, Annalisa
AU  - Fleischhauer, Katharina
AU  - Bonini, Chiara
TI  - Hematopoietic stem cell transplantation in its 60s: A platform for cellular therapies
AID  - 10.1126/scitranslmed.aap9630
DP  - 2018 Apr 11
TA  - Science Translational Medicine
PG  - eaap9630
VI  - 10
IP  - 436
4099  - http://stm.sciencemag.org/content/10/436/eaap9630.short
4100  - http://stm.sciencemag.org/content/10/436/eaap9630.full
AB  - Over the last 60 years, more than a million patients received hematopoietic cell transplantation. Having incorporated multiple changes in clinical practices, it remains a complex procedure facing a dual challenge: cure of the underlying disease and prevention of relapse while controlling potentially severe complications. Improved understanding of underlying biological processes resulted in the design of innovative therapies engineered from defined cell populations and testing of these therapies as addition or substitution at virtually every step of the procedure. This review provides an overview of these developments, many of them now applied outside the historical field of hematopoietic cell transplantation.