RT Journal Article
SR Electronic
T1 Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP eaan5174
DO 10.1126/scitranslmed.aan5174
VO 10
IS 426
A1 Lemos, Dario R.
A1 Duffield, Jeremy S.
YR 2018
UL http://stm.sciencemag.org/content/10/426/eaan5174.abstract
AB Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.