RT Journal Article SR Electronic T1 Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies JF Science Translational Medicine FD American Association for the Advancement of Science SP eaan5174 DO 10.1126/scitranslmed.aan5174 VO 10 IS 426 A1 Lemos, Dario R. A1 Duffield, Jeremy S. YR 2018 UL http://stm.sciencemag.org/content/10/426/eaan5174.abstract AB Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell (MSC) populations residing in different organs revealed unique properties and lineage capabilities that vary from one anatomical location to another. We review recently characterized tissue-resident MSC populations with a prominent role in fibrosis and highlight therapeutically relevant molecular pathways regulating their activity in chronic disease.