RT Journal Article
SR Electronic
T1 Vasopressin stimulates the proliferation and differentiation of red blood cell precursors and improves recovery from anemia
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP eaao1632
DO 10.1126/scitranslmed.aao1632
VO 9
IS 418
A1 Mayer, Balázs
A1 Németh, Krisztián
A1 Krepuska, Miklós
A1 Myneni, Vamsee D.
A1 Maric, Dragan
A1 Tisdale, John F.
A1 Hsieh, Matthew M.
A1 Uchida, Naoya
A1 Lee, Heon-Jin
A1 Nemeth, Michael J.
A1 Holmbeck, Kenn
A1 Noguchi, Constance Tom
A1 Rogers, Heather
A1 Dey, Soumyadeep
A1 Hansen, Arne
A1 Hong, Jeffrey
A1 Chow, Ian
A1 Key, Sharon
A1 Szalayova, Ildikó
A1 Pagani, Jerome
A1 Markó, Károly
A1 McClain-Caldwell, Ian
A1 Vitale-Cross, Lynn
A1 Young, W. Scott
A1 Brownstein, Michael J.
A1 Mezey, Éva
YR 2017
UL http://stm.sciencemag.org/content/9/418/eaao1632.abstract
AB Vasopressin is an antidiuretic hormone, whose best known functions are to promote water retention and maintain fluid balance. However, it also has other effects, and Mayer et al. discovered that these include stimulation of red blood cell maturation. By studying human patients with central diabetes insipidus (vasopressin deficiency) and a rat model that lacks vasopressin, the authors determined that this hormone acts in concert with erythropoietin but on a shorter time scale. Erythropoietin stimulates red blood cell production starting with early progenitors, which takes time, whereas vasopressin promotes maturation of intermediate red blood cell precursors and thus allows rapid recovery after blood loss while the new cells stimulated by erythropoietin are still maturing.Arginine vasopressin (AVP) made by hypothalamic neurons is released into the circulation to stimulate water resorption by the kidneys and restore water balance after blood loss. Patients who lack this antidiuretic hormone suffer from central diabetes insipidus. We observed that many of these patients were anemic and asked whether AVP might play a role in red blood cell (RBC) production. We found that all three AVP receptors are expressed in human and mouse hematopoietic stem and progenitor cells. The AVPR1B appears to play the most important role in regulating erythropoiesis in both human and mouse cells. AVP increases phosphorylation of signal transducer and activator of transcription 5, as erythropoietin (EPO) does. After sublethal irradiation, AVP-deficient Brattleboro rats showed delayed recovery of RBC numbers compared to control rats. In mouse models of anemia (induced by bleeding, irradiation, or increased destruction of circulating RBCs), AVP increased the number of circulating RBCs independently of EPO. In these models, AVP appears to jump-start peripheral blood cell replenishment until EPO can take over. We suggest that specific AVPR1B agonists might be used to induce fast RBC production after bleeding, drug toxicity, or chemotherapy.