RT Journal Article
SR Electronic
T1 Comment on “Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice”
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 350le2
OP 350le2
DO 10.1126/scitranslmed.aaf4379
VO 8
IS 350
A1 Guerra, Emanuela
A1 Piantelli, Mauro
A1 Alberti, Saverio
YR 2016
UL http://stm.sciencemag.org/content/8/350/350le2.abstract
AB In ApcMin mice (an animal model of colorectal carcinogenesis) fed a high-fat diet, low doses of resveratrol suppress intestinal adenoma development more potently than high doses do; however, these findings appear affected by multiple confounding factors, as resveratrol alone added to a standard diet has opposite outcomes.