PT - JOURNAL ARTICLE AU - Guerra, Emanuela AU - Piantelli, Mauro AU - Alberti, Saverio TI - Comment on “Cancer chemoprevention: Evidence of a nonlinear dose response for the protective effects of resveratrol in humans and mice” AID - 10.1126/scitranslmed.aaf4379 DP - 2016 Aug 03 TA - Science Translational Medicine PG - 350le2--350le2 VI - 8 IP - 350 4099 - http://stm.sciencemag.org/content/8/350/350le2.short 4100 - http://stm.sciencemag.org/content/8/350/350le2.full AB - In ApcMin mice (an animal model of colorectal carcinogenesis) fed a high-fat diet, low doses of resveratrol suppress intestinal adenoma development more potently than high doses do; however, these findings appear affected by multiple confounding factors, as resveratrol alone added to a standard diet has opposite outcomes.