RT Journal Article
SR Electronic
T1 Antibiotics, birth mode, and diet shape microbiome maturation during early life
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 343ra82
OP 343ra82
DO 10.1126/scitranslmed.aad7121
VO 8
IS 343
A1 Bokulich, Nicholas A.
A1 Chung, Jennifer
A1 Battaglia, Thomas
A1 Henderson, Nora
A1 Jay, Melanie
A1 Li, Huilin
A1 D. Lieber, Arnon
A1 Wu, Fen
A1 Perez-Perez, Guillermo I.
A1 Chen, Yu
A1 Schweizer, William
A1 Zheng, Xuhui
A1 Contreras, Monica
A1 Dominguez-Bello, Maria Gloria
A1 Blaser, Martin J.
YR 2016
UL http://stm.sciencemag.org/content/8/343/343ra82.abstract
AB The intestinal “microbiota,” that is, the community of microbes inhabiting the human intestinal tract, undergoes many changes during the first 2 years of life. Bokulich et al. now show that this pattern of development is altered in children who are delivered by cesarean section, fed formula, or treated with antibiotics, compared to those babies who were born vaginally, breast-fed, or unexposed to antibiotics. Future studies will determine whether these disturbances influence the health of these babies.Early childhood is a critical stage for the foundation and development of both the microbiome and host. Early-life antibiotic exposures, cesarean section, and formula feeding could disrupt microbiome establishment and adversely affect health later in life. We profiled microbial development during the first 2 years of life in a cohort of 43 U.S. infants and identified multiple disturbances associated with antibiotic exposures, cesarean section, and formula feeding. These exposures contributed to altered establishment of maternal bacteria, delayed microbiome development, and altered α-diversity. These findings illustrate the complexity of early-life microbiome development and its sensitivity to perturbation.