RT Journal Article
SR Electronic
T1 Targeting the glucocorticoid receptor in breast and prostate cancers
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 305ps19
OP 305ps19
DO 10.1126/scitranslmed.aac7531
VO 7
IS 305
A1 Kach, Jacob
A1 Conzen, Suzanne D.
A1 Szmulewitz, Russell Z.
YR 2015
UL http://stm.sciencemag.org/content/7/305/305ps19.abstract
AB Steroid receptors for androgens and estrogens have essential roles in prostate and breast cancers. Recently, glucocorticoid receptor (GR) activity has also been proposed as having an important role in these cancers. Underscoring the cooperative nature of nuclear receptor activity, data now suggest that GR function in prostate and breast cancers is dependent on the tumor’s concomitant androgen or estrogen receptor activity.