RT Journal Article
SR Electronic
T1 Comment on “Drug Discovery: Turning the Titanic”
JF Science Translational Medicine
FD American Association for the Advancement of Science
SP 229le2
OP 229le2
DO 10.1126/scitranslmed.3008763
VO 6
IS 229
A1 Lesterhuis, W. Joost
A1 Bosco, Anthony
A1 Lake, Richard A.
YR 2014
UL http://stm.sciencemag.org/content/6/229/229le2.abstract
AB The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.