PT  - JOURNAL ARTICLE
AU  - Lesterhuis, W. Joost
AU  - Bosco, Anthony
AU  - Lake, Richard A.
TI  - Comment on “Drug Discovery: Turning the Titanic”
AID  - 10.1126/scitranslmed.3008763
DP  - 2014 Mar 26
TA  - Science Translational Medicine
PG  - 229le2--229le2
VI  - 6
IP  - 229
4099  - http://stm.sciencemag.org/content/6/229/229le2.short
4100  - http://stm.sciencemag.org/content/6/229/229le2.full
AB  - The pathobiology-based approach to research and development has been the dominant paradigm for successful drug discovery over the last decades. We propose that the molecular and cellular events that govern a resolving, rather than an evolving, disease may reveal new druggable pathways.