RT Journal Article SR Electronic T1 The A4 Study: Stopping AD Before Symptoms Begin? JF Science Translational Medicine FD American Association for the Advancement of Science SP 228fs13 OP 228fs13 DO 10.1126/scitranslmed.3007941 VO 6 IS 228 A1 Sperling, Reisa A. A1 Rentz, Dorene M. A1 Johnson, Keith A. A1 Karlawish, Jason A1 Donohue, Michael A1 Salmon, David P. A1 Aisen, Paul YR 2014 UL http://stm.sciencemag.org/content/6/228/228fs13.abstract AB A new secondary prevention trial in older people with amyloid accumulation at high risk for Alzheimer’s disease dementia should provide insights into whether anti-amyloid therapy can delay cognitive decline.