PT - JOURNAL ARTICLE AU - Bilican, Bilada AU - Serio, Andrea AU - Barmada, Sami J. AU - Nishimura, Agnes Lumi AU - Sullivan, Gareth J. AU - Carrasco, Monica AU - Phatnani, Hemali P. AU - Puddifoot, Clare A. AU - Story, David AU - Fletcher, Judy AU - Park, In-Hyun AU - Friedman, Brad A. AU - Daley, George Q. AU - Wyllie, David J. A. AU - Hardingham, Giles E. AU - Wilmut, Ian AU - Finkbeiner, Steven AU - Maniatis, Tom AU - Shaw, Christopher E. AU - Chandran, Siddharthan TI - Comment on “Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells” AID - 10.1126/scitranslmed.3005065 DP - 2013 Jun 05 TA - Science Translational Medicine PG - 188le2--188le2 VI - 5 IP - 188 4099 - http://stm.sciencemag.org/content/5/188/188le2.short 4100 - http://stm.sciencemag.org/content/5/188/188le2.full AB - Egawa et al. recently showed the value of patient-specific induced pluripotent stem cells (iPSCs) for modeling amyotrophic lateral sclerosis in vitro. Their study and our work highlight the need for complementary assays to detect small, but potentially important, phenotypic differences between control iPSC lines and those carrying disease mutations.